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5.1 cAMP/PKA/CREB signaling pathway The cAMP/PKA/CREB signaling pathway, also known as the cAMP-dependent pathway, has a role in regulating neuronal growth and development, synaptic plasticity, neurogenesis and memory consolidation (48, 142)

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Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective