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In retatrutides TRIUMPH-1 trial, the highest-dose group reported nausea in 42.4% of participants, diarrhea in 32.0%, constipation in 26.1%, and vomiting in 25.3% a higher overall GI burden, which tracks with retatrutides larger effect size and third receptor target

After 12 months of treatment, compared with those on semaglutide alone, women who were taking both MHT and semaglutide: showed an improved weight loss response achieved about 30% more total body weight loss The reasons for this association are unknown, though the authors propose that it may be due to MHT improving other quality of life measures

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