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The inhibition, which shows dose dependency, is exerted via interactions with receptors in the brain that are accessible via leaks in the blood-brain barrier of the circumventricular organs, mainly the postrema area, the subfornical organ and the median eminence [10, 11]

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Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

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However, persistent severe nausea lasting beyond two weeks, vomiting, or inability to keep fluids down warrants immediate contact with your healthcare provider to rule out other causes and discuss dose adjustments