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In a phase 2 clinical trial, CagriSema reduced HbA1c by 2.2% (p = 0.075) in comparison with semaglutide 2.4 mg alone [101]
R., Bodell, L

The FDA issued a warning about these formulations.12 Isaacs also raises safety concerns about obtaining these medications online and from other countries

For individuals with severe obesity (BMI over 40 kg/m) or those who have failed other interventions, tirzepatide offers the greatest likelihood of achieving substantial weight reduction

Switching to retatrutide before exploring the full tirzepatide dose range means you may be abandoning a simpler solution
