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Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE-TIMI 58 randomised trial

Especially in American and European regions, at least 50% of residents now weigh more than the international standardized body mass index (BMI) recommends [3]

Most of the subjects included in the available RCTs are PCOS patients with severe obesity, which do not reflect the entire clinical spectrum of PCOS encountered in clinical practice

This new trial built on a previous one published in NEJM last fall (I previously reviewed here) for the same indication, but the only difference was the inclusion of people with diabetes

A November 2025 KFF Health Tracking Poll found that roughly 1 in 8 U.S