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Animal experiments shown in Figures 1C , 2 , and 3 and Supplementary material online, Figures S2 and S3 , were performed by S.V

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Secondary endpoints at the 12mg dose included: fasting insulin reduction of 41%, triglyceride reduction of ~40%, waist circumference reduction of 18.5 cm, and meaningful improvements in liver fat fraction on MRI in a subset of participants