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It affects the smaller joints first: fingers, wrists, and the balls of the feet

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In addition, recent studies suggest that GLP-1s may be linked with a rare yet serious condition called nonarteritic anterior ischemic optic neuropathy (NAION)

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One route may reflect the cost of the material itself

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DPP-4i: 1.03, 95% CI 0.71, 1.49), self-harm (HR: 0.92, 95% CI 0.73, 1.17), and suicide (HR: 0.75, 95% CI 0.30, 1.86)

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Both are on formulary in 2026, typically Tier 2 or 3 with PA

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