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Clinical Evidence for Semaglutide-Naltrexone Combination The strongest evidence for semaglutide plus naltrexone comes from the IMCOSI phase 2b trial (2021), which enrolled 338 patients and found that the combination resulted in approximately 20% body weight loss over 48 weeks, compared to 16% for semaglutide alonea difference that was statistically significant but modest in absolute terms

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