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Monitor renal function closely if vomiting or diarrhea persists on therapy

In addition, exendin 4 exerted renoprotective effects in animal models through inhibition of nuclear factor-B (NF-B) activity in the kidney, and elevated NF-B activity is known to contribute to the crosstalk between inflammation and oxidative stress 96

The Grading of Recommendations Assessment, Development and Evaluation framework (GRADE) system was applied to assess the certainty of evidence for each outcome

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