glp 1 and vagus nerve GLP-1 the Degenerating Brain: Exploring Mechanistic Insights and Therapeutic Potential GLP-1 Agonists and the Vagus

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, Chang, R

Semaglutide treatment of antipsychotic-treated patients with schizophrenia, prediabetes, and obesity: the HISTORI randomized clinical trial

Pharmacologically mediated marked initial maternal body weight loss and reductions in body weight gain and food consumption coincided with an increase in early pregnancy losses and led to delivery of slightly smaller offspring at 0.075 mg/kg twice weekly (6X human exposure)

On the scientific risk side, it appeared unlikely that the next obesity drug would succeed against all odds when numerous candidates have historically shown limited efficacy & tolerability in the clinic