glp-1 receptor agonist antipsychotic weight gain study and Metabolic Syndrome (MetS) The Weight-loss Effect of GLP-1RAs

doi:10.1111/cns.12866 de la Monte SM, Wands JR

Selected regions are labelled

Ongoing concerns associated with GLP-1 RA use are the potential for weight gain after stopping treatment and long-term adherence due to AEsalthough the investigators noted that the most common GI AEs tend to diminish with longer use and are more pronounced during initial treatment

Furthermore, liraglutide suppressed DNA fragmentation and the activity of matrix metalloproteinases-2 (MMP-2) and 9(MMP-9), while upregulating superoxide dismutase and IL-10 in the sciatic nerve [12]

Activation of the GLP-1 receptor signalling pathway: A relevant strategy to repair a deficient beta-cell mass