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Limitations and Future Perspectives The currently available evidence is limited by the underlying heterogeneity in patient characteristics, comorbidities, study designs, and practice protocols of the participating institutions

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Without his determination, exendin-4 might have remained a footnote in the toxinology literature rather than becoming the foundation of a therapeutic revolution

This creates a strong incentive to maintain treatment, even in the face of inconvenience or mild side effects

A separate rapid review published in Obesity Reviews in late 2025 by Jebeile and colleagues, which analyzed 25 studies, found that binge eating episodes and prevalence were reduced following treatment with liraglutide and semaglutide