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Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which typically diminish over time with continued use and gradual dose escalation

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Another meta-analysis of patients with type 2 diabetes, overweight or obesity also found that when oral hypoglycemic drugs, insulin or lifestyle interventions were used as controls, there was no significant difference in the effect of GLP-1RAs on lean mass and lean mass percentage [57]

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GLP-1 is an incretin hormone produced by intestinal L-cells that stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and promotes satiety in response to food intake