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GLP-1RAs have been shown to protect the heart from oxidative stress and reduce the expression of pro-inflammatory cytokines (interleukin (IL)-1, TNF-, IL-6, and monocyte chemoattractant protein-1 (MCP-1)) in the myocardium

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But Amazon's edge is in same-day delivery and convenience as it looks to leverage its logistics network and consumer reach into another corner of the medical system

A subsequent meta-analysis involving six major cardiovascular and kidney outcome trials confirmed these early observations, showing a 36% reduction in composite kidney outcomes regardless of baseline ASCVD status [45]

Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]