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SF: Data curation, Writing original draft, Writing review & editing, Formal Analysis, Investigation

Eat smaller, more frequent meals with bland foods, stay well-hydrated, avoid high-fat or spicy foods, and follow the prescribed dose escalation schedule

Memantine, a noncompetitive NMDA receptor antagonist, attenuates glutamate-induced excitotoxicity by non-competitively blocking overactivated receptors, thereby protecting neurons from calcium overload and providing modest preservation of daily functioning in moderate-to-severe AD, but similarly fails to modulate tau pathology or proteostatic mechanisms [80]

Alzate-Vinasco are employees of Novo Nordisk, the sponsor of the research project from which this work was derived

PMID: 30 KhayachiANunesAAldaMRouleauGA