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Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close

doi: 10.1126/scitranslmed.3007218 32 DelmeireDFlamezDMoensKHinkeSAVan SchravendijkCPipeleersDet al

Eli Lillys Misleading Marketing Strategy Promoting Trulicity Since Trulicitys launch in 2014, there have been a number of concerns about Eli Lillys marketing strategy

Amgen, Viking Therapeutics, Boehringer Ingelheim, Zealand Pharma, and Pfizer are also important watchlist companies

6 , 712.e11 (2014)