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Cardiovascular benefit was largely independent of overall weight loss, with waist circumference reduction explaining only part of the effect.

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Results At 1 year, patients achieved significant weight loss with a median total weight loss (%TWL) of 25.5% and a median excess weight loss (%EWL) of 66.3% compared to 16.6% and 40.8%, respectively, at treatment initiation with BMI reduction of 3.7 kg/m2

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