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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are gaining increasing attention as first-line agents for the treatment of diabetes and obesity, and with their potential to improve the muscle mass and function, they provide new ideas for the treatment of sarcopenia

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The blood-brain barrier (BBB) serves as a defensive line protecting the central nervous system, while also maintaining micro-environment homeostasis and inhibiting harmful materials from the peripheral blood

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In contrast, co-administration of Vutiglabridin overcame this attenuation of efficacy, enabling continuous weight reduction and achieving normal body composition