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This will inevitably keep the preventative use of GLP-1 agonists off label for a long time if not forever

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But for most people, it happens very, actually suddenly, and it goes away absolutely, completely despite continuation of the drug, said Marzieh Salehi, an endocrinologist and researcher studying the cross-communication between the gut and other organs at the University of Texas Health at San Antonio

If youre tolerating the medication well and not losing weight drastically, you may be advised to move up to the next higher dose, as higher doses are associated with more weight loss

Examples of long-term side effects reported with Rybelsus include: pancreatitis (inflammation of the pancreas) kidney problems, such as kidney failure boxed warning: risk of thyroid cancer To learn more about some of these side effects, see the Side effects explained section