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102 Together, these examples demonstrate that Boolean OR gating is not merely a theoretical construct but a clinically viable approach to broaden the therapeutic window

The trial also assessed clinically meaningful thresholds: over 90% of participants on 4 mg or higher doses lost at least 5% of body weight, and 6083% of them reached 15% or greater reduction, compared with just 27% and 2%, respectively, in the placebo group

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