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injections of 10 nmol kg 1 semaglutide ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice) or vehicle (isotonic saline, n = 8 mice) at a volume of 5 l g 1
Constipation tends to be dose-dependent with GLP-1 medications

The side effect profile is similar in type, with nausea, constipation, and diarrhea being most common, but the severity and tolerability may differ due to the different receptor activation pattern

51 Correspondingly, in the phase 1b/2a trial, individuals treated with once-weekly s.c
The safety and effectiveness of recently developed and future expected obesity drugs combined with other treatment modalities (such as bariatric surgery or drastic lifestyle changes) need to be further investigated
