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Adaptation in Chronic Low Sodium Level In chronic hyponatremia , which develops over days to weeks: Brain cells gradually expel osmolytes to reduce intracellular swelling Cerebral adaptation limits the degree of edema Because of this adaptation: Symptoms may be mild or nonspecific Patients may tolerate very low serum sodium with relatively few neurologic signs However, this adaptation also creates vulnerability

Seferovi PM, Fragasso G, Petrie M, Mullens W, Ferrari R, Thum T, et al

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Ulcerative Colitis Patients Have Reduced Rectal Compliance Compared With Non-Inflammatory Bowel Disease Controls

MACE (Major Adverse Cardiovascular Events) : endpoint composito cardiovascolare comunemente utilizzato nei grandi trial di sicurezza, comprendente infarto miocardico non fatale, ictus non fatale e morte cardiovascolare