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Paradoxically, despite the absence of thermogenesis via mitochondrial uncoupling, UCP1 null mice are not more susceptible to weight gain than wild-type mice on a high-fat diet, even when housed at thermoneutrality (30C) [123]

Monotherapy Treatment using a single medication without combining it with other drugs

These symptoms can further reduce food intake and may require temporary dietary modifications, such as eating smaller, more frequent meals and avoiding high-fat or spicy foods that may exacerbate nausea

Most patients on tirzepatide experience steady, sustainable weight loss of 12 pounds per week, which translates to meaningful liver fat reduction within 612 months
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