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Exposing three human osteosarcoma cell lines expressing GIPRs (TE-85, MG-63, and Saos-2) to GIP resulted in the release of bone formation marker P1NP (Pacheco-Pantoja et al., 2011), in which the expression of Col-1 in Saos-2 cells increased (Mieczkowska et al., 2015)

They exist throughout the central and peripheral nervous system

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A 2022 observational study from the American Spine Journal reported that overweight patients who lost more than 10% of their body weight experienced significant reductions in lower back pain intensity and frequency