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These symptoms typically occur during treatment initiation or dose escalation and often improve over time, though they can be severe enough to necessitate discontinuation in some patients

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By focusing on two specific representatives of two distinct classes of weight reducing agents, liraglutide and FGF21, in combination with our monoclonal leptin neutralizing antibodies, we demonstrate that leptin reduction acts as a common mechanism for weight loss and improvement in metabolic disorders, including diabetes and liver fibrosis

Thus, less frequent and smaller meals are recommended, which would predispose patients to biliary sludge, gallstone formation and slowed biliary motility

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