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Conte C, Hall KD, Klein S

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Appetite suppression and weight loss are expected pharmacological effects of Rybelsus, resulting from its action on satiety centres in the brain and delayed gastric emptying

Mechanistically, L-tryptophan upregulated the expression of GLP-1related genes (e.g., Gcg and Pcsk1 ) in intestinal L cells, further promoting GLP-1 production ( In contrast, some postbiotics may suppress GLP-1 signaling
