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Treatment should only continue if there is a reduction in HbA1c of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight after 6 months

Mechanistic comparison studies published pharmacological analyses confirm that Retatrutides GCGR activity produces statistically significant increases in resting energy expenditure versus dual agonists

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Participants in major trials lost anywhere from 15% to over 20% of their body weight, results that had previously only been associated with bariatric surgery

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