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But if someone has a lot of weight to lose then the absolute number may sound like a lot, but really for their particular body, may not be as much as we think it is. Pearlman pointed out that every person is different and they may react differently to weight loss drugs

Association between variants in TCF7L2, CTRB1/2, and GLP-1R genes and response to therapy with glucagon-like peptide-1 receptor agonists

Sandoval and DAlessio (2015)

I feel conflicted about that, because I'm not somebody who hated my fat body