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Our transcriptomic data indicate a remodeling of the LPD liver transcriptome in response to semaglutide (Fig 4)

First, GLP-1 receptor agonists carry an FDA black box warning about thyroid C-cell tumors based on animal studies, and while the clinical relevance in humans remains uncertain, the warning does mean patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 should not take these medications

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Semaglutide weight loss injections are incretin mimetics, i.e., they enable the pancreas to release the perfect amount of insulin when blood sugar levels are high

Any weight gain that happens around the time melatonin is started is more likely to be due to indirect effects, which in some cases could contribute to weight gain