fda compounding semaglutide news november 2025 Important Update: Changes to Compounded Availability US FDA proposes curbs on

No rigid rules

[11] [12] However, this guarantee does not extend beyond the expiration date, and using expired semaglutide is not recommended by manufacturers or regulatory authorities

These findings are generally attributed to weight loss and improved metabolic status rather than direct thyroidal effects, although the underlying mechanisms remain unclear

These include but are likely not limited to chronic hyperglycemia, hypertension, dyslipidemia, obesity, insulin resistance, sodium retention, neurohormonal activation and low-grade inflammation, all related to the metabolic syndrome [9, 10]

In his experience, someone who has multiple medications for conditions like blood pressure, depression, and chronic pain is likely to develop issues with constipation especially if they add a GLP-1, he says