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*Correspondence: Jing-Dong Xu, [email protected] This article was submitted to Gut Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Constipation sometimes persists longer, but nausea typically resolves well before your maintenance phase begins
Semaglutide, marketed under brand names such as Wegovy and Ozempic, is an FDA-approved medication initially used for type 2 diabetes and weight management

By activating both pathways, tirzepatide enhances insulin secretion when glucose levels are elevated, improving metabolic outcomes more comprehensively than GLP-1 alone

Additional studies have indicated that GLP-1 enhances endothelial function in diabetic vasculature by reducing endothelial permeability and contractility, while also offering protection against oxidative stress and autophagic processes [111,112]
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