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Nevertheless, current evidence supports GLP-1 RAs and multi-agonist formulations as highly promising pharmacotherapies that address the complex, multifactorial pathophysiology of MASLD while simultaneously improving cardiometabolic comorbidities, positioning them as cornerstone treatments in the evolving therapeutic landscape for this prevalent and burdensome disease

doi: 10.1136/bmj.b496, 106 NeratziS.SergentanisT.TsitsikaA

This activates adenylylate cyclase (AC), which increases cAMP

255 GLP-1(7-36) stimulates the release of paracrine glucagon inhibitory factors by activating GLP-1R on -cells and -cells

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