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Nevertheless, current evidence supports GLP-1 RAs and multi-agonist formulations as highly promising pharmacotherapies that address the complex, multifactorial pathophysiology of MASLD while simultaneously improving cardiometabolic comorbidities, positioning them as cornerstone treatments in the evolving therapeutic landscape for this prevalent and burdensome disease

This is less than semaglutide (Rybelsus 15-17%) and high-dose Wegovy injection 15-18%

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More recently, dual and triple agonists targeting additional incretin and metabolic hormone receptors have demonstrated enhanced therapeutic potential, revolutionizing the landscape of MASLD treatment [11,12]

While GLP1s have been around almost 20 years, initially approved as a treatment for type 2 diabetes, theyve recently been catapulted into the public domain due to their demonstrated effectiveness as a weight loss agent