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Observed outcomes in study environments have included changes in biomarkers associated with metabolic function and body weight parameters

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These data unveil a new central role for GIPR signaling and identify a potentially important cell type expressing both GLP-1R and GIPR upon which tirzepatide or other dual agonists may modulate DA homeostasis in the brain.

The first study shows that more economical and sustainable weight loss can be maintained by inducing subjects with tirzepatide and changing to oral orforglipron for the long term