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The correlation between genotype and phenotype in PWS remains unclear, as none of the genes in the PWS region have been specifically implicated in the syndrome on their own ( SNORD116

[DOI] [PubMed] [Google Scholar] [39].Singh P, Zeng X, Chen X, Yang Y, Chen Y, Cui S, Carrier A, Oakes K, Luan T, Zhang X, Quantitation of polymeric-microneedle-delivered HA15 in tissues using liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 185 (2020) 113230

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In a rodent model, a novel GLP-1R/GIPR/GCGR triple agonist, SAR441255, has been shown to promote weight loss and the maintenance of healthy blood glucose levels and is superior to the GLP-1R/GCGR dual agonist (Saxena et al., 2023)