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Since its clinical application in 1957, metformins cornerstone status has remained consistent and it is still the first-line preferred treatment for type 2 diabetes mellitus (T2DM) side by side with lifestyle (Montvida et al., 2018

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Most (all?) of these effects were apparently transmitted via inhibition of efferent vagus nerve activity (67, 68), providing early suggestions of powerful actions of GLP-1 via hindbrain and hypothalamic mechanisms

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Diabetes and Vascular Disease Research 11419430

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