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Since its clinical application in 1957, metformins cornerstone status has remained consistent and it is still the first-line preferred treatment for type 2 diabetes mellitus (T2DM) side by side with lifestyle (Montvida et al., 2018

Most (all?) of these effects were apparently transmitted via inhibition of efferent vagus nerve activity (67, 68), providing early suggestions of powerful actions of GLP-1 via hindbrain and hypothalamic mechanisms

Diabetes and Vascular Disease Research 11419430
