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However, their effects are not uniformly beneficial

Long-term use of beta-glucan at 3 g/day has been found to give additional advantages in diabetes treatment [51]

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While these mechanisms make them highly effective, they also predispose patients to gastrointestinal adverse effects, such as nausea, vomiting, abdominal discomfort, and constipation

35 Therefore, SGLT-2is is highly recommended for treating T2D patients with a risk of heart failure and diabetic retinopathy