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T lymphocyte function is modulated through inhibition of pro-inflammatory Th17 differentiation and promotion of regulatory T cell (Treg) expansion via STAT5-dependent mechanisms [42,43]

Most require a prescription and diagnosis documentation showing medical necessity (obesity with BMI over 30, or BMI over 27 with weight-related comorbidities)

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Diabetologia 2016;59:1121-40

Switching to semaglutide can refresh receptor sensitivity and provide a bridge into long-term weight management with less aggressive suppression
