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However, rapid weight loss, nutrient depletion, and metabolic shifts during therapy may temporarily worsen or unmask existing subclinical neuropathy
Kleinschmidt, Genve (Neurologie)
While Semaglutide generally has milder side effects that subside over time, Phentermine carries a higher risk of cardiovascular side effects and should be used cautiously, especially in individuals with heart concerns
However, as mentioned previously for vagal afferent regulation of food intake, recent work has failed to demonstrate an effect of food intake via direct gut peptide signaling on VAN-localized receptors
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