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These SCFAs not only nourishes colon cells and reduces inflammation, but also stimulates GLP-1 secretion via G-protein-coupled receptors

Tirzepatide was associated with dose-dependent reductions in body weight with a LSM difference of 5.8 kg (7.8% reduction), 8.5 kg (11.0% reduction), and 10.7 kg (13.9% reduction) for 5 mg, 10 mg, 15 mg, of tirzepatide, respectively, compared with 0.5 kg (0.7% reduction) for dulaglutide

In many online prescribing models, oversight is limited

Another oral, non-peptide GLP-1 RA (lotiglipron) has also been withdrawn from development as in early phase clinical trials resulted in elevated liver enzymes which could indicate liver toxicity [30]

Im also interested in how we get people off the drugs once theyve lost the weight