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In animal studies, SGLT2 inhibitors were generally safe during the first trimester but exposure during postnatal day 21 to 90 in juvenile rats, a period coinciding with the late second and third trimester of human renal development, caused dilatation of the renal pelvis and tubules

Traditional approaches to managing pediatric obesity and MASLD, such as lifestyle modifications and dietary interventions, have shown limited long-term success
