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Diabetes Metab Res Rev 31(3):248255 Vasu S, Moffett RC, Thorens B, Flatt PR (2014) Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress

The SURPASS clinical trial program did not identify increased cardiovascular events with tirzepatide compared to placebo or active comparators, though dedicated cardiovascular outcome trials are still ongoing

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