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This work has benefited from the facilities and expertise of IECB Biophysical and Structural Chemistry platform (BPCS), CNRS UMS3033, Inserm US001, Univ

doi:10.1172/jci.insight.140532 57

Week 1-2: Foundations Calculate and track protein intake

mean follow-up: 4.91 years), and the as-treated analysis showed greater risk reduction (HR 0.70, 95% CI 0.600.82

The rationale is that fasting-induced hormonal shifts (higher GLP-1, altered ghrelin, improved insulin sensitivity) may synergize with medication-delivered GLP-1 for amplified effect
