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An overview table of included studies is available in the Supplementary Material (S1) and online with options to filter the database ( The table includes information on first author and year of publication (1), paper title (2), whether the study was included in the meta-analysis (3) or systematic review (4), a tag indicating whether ghrelin or GLP-1 was investigated (5), specification of the hormonal assessment and/or manipulation (i.e., whether plasma acyl-, desacyl-, total ghrelin, GLP-1 was measured, which substance was administered (if any)) (6), type of reward phase assessed during fMRI (7), type of reward (e.g., food, money, alcohol) (8), and sample population(s) (9)

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And the study protocol registered to UMIN-CTR (No.UMIN000024556) approved by International Committee of Medical Journal Editors (ICMJE)

If nausea is severe or worsening beyond the first 2 weeks, discuss it with your providerit may signal a need to adjust your dose, meal timing, or diet composition rather than indicating the medication is more effective

With the growing popularity of GLP-1 medications like semaglutidefound in brand names such as Wegovy and Ozempicmany patients are seeking guidance on which option is best for their unique needs