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Further supporting the role of Pax6 in regulating intestinal Gcg expression, adenoviral overexpression of Pax6 enhances Gcg promoter activity and Gcg expression in intestinal enteroendocrine cells such as the secretin tumor cell line-1 (STC-1) and cells derived from colonic tumors of transgenic mice expressing large T antigen under the control of the proglucagon promoter (GLUTag cells) [108]
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A typical combination might include a GLP-1 agonist as the primary weight loss driver, a GH secretagogue for body composition optimization, and a healing peptide like BPC-157 for GI support
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