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The latter is often associated with a concurrent sinus venosus defect connecting the RA and LA

It is important that you eat a magnesium-rich diet with nuts, seeds, avocados, and cacao, and also supplement with magnesium (39)

Prolonged use risks addiction and tolerance, reducing effectiveness

The absence of high-quality evidence means prescribers who recommend this combination are making an educated guess based on mechanistic reasoning rather than proven patient outcomes

However, when combined with sulfonylureas or insulin, dose adjustments of these concomitant medications may be necessary to prevent hypoglycaemic episodes