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The Synergistic Effect of Hormone Replacement Therapy and GLP-1 Medications on Weight Loss: What Recent Research Reveals

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In the largest pharmacogenomics GWAS of GLP-1 medications to date (15,237 participants, replicated in the All of Us cohort), researchers identified a missense variant in GLP1R the gene encoding the very receptor that semaglutide and tirzepatide bind that significantly predicts how much weight a person loses on treatment