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Options include holding the dose and not escalating further, dropping back to the previous dose, switching to the other medication, adding supportive medications for specific symptoms, or in rare cases, discontinuing treatment entirely

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NICEs willingness to pay more hints that somewhat higher drug prices (and thus higher global price floors) might become acceptable at least temporarily in the UK

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Discussion Our experience speaks to several complications of the long-term management of antipsychotic-induced weight gain and the use of GLP-1R agonists in schizophrenia