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They help people lose weight by working in both the gut and the brain, acting on digestion, insulin and appetite, helping quiet cravings and what users describe as food noise. So named for the GLP-1 hormone they mimic, the medicines have also shown success in cardiovascular disease, heart failure, sleep apnea and kidney disease

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It has therefore been proposed that tastants present in the amniotic fluid, which are influenced by the maternal diet, may already prime early taste preferences in the developing fetus and thereby contribute to the development of obesity in later life [57]