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These drugs are essential to prevention of rejection but come at a metabolic cost, disrupting glucose metabolism through several mechanisms, including downregulation of transcription of the adiponectin gene which can lead to greater risk for glucose intolerance

Kidney Res Clin practice (2022) 41(2):13649

For researchers considering a taper schedule, the dosage calculator can help plan the exact reconstitution volumes needed at each reduced dose tier

In addition, many patients do not stay on these treatments for more than a year and can rapidly regain much of their body weight, with almost all of the regained weight due to fat 3,6,10,36

Step 2: Assess risk features Determine whether the patient is in dose escalation, has active GI symptoms, uses a high dose, has known gastroparesis, has long-standing diabetes with autonomic neuropathy, has severe GERD or hiatal hernia, or is undergoing general anesthesia/deep sedation